The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) is a clinical trials network funded by the National Institute for Neurological Disorders and Stroke (NINDS), the National Heart Lung and Blood Institute (NHLBI) and the National Center for Advancing Translational Science (NCATS). The goal of SIREN is to improve the outcomes by identifying effective treatments given in the earliest stages of care.
The Southwest Network Clinical Center (Hub) for SIREN Emergency Care Clinical Trials is a cooperative center with co-equal components based at UCLA and Harbor-UCLA. Together, the Hub oversees activities at spoke sites throughout the Southwest region that serve as performance sites. SIREN projects at Harbor-UCLA include POST-ICECAP (Patterns of Survivors’ Recovery Trajectories in the ICECAP Trial) and KESETT (Ketamine add-on therapy for Established Status Epilepticus Treatment Trial).